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公司的核心团队具有资深的基因组专业背景和丰富的行业经验,对相关技术和产业的现状、发展趋势等具有深刻的认识和了解。核心团队成员具有优秀的学术素养,目前已在 Nature、Science 等顶尖学术期刊发表多篇学术论文。


团队成员自2007 年起开始负责国内首批新一代测序实验平台的搭建,是我国测序平台发展的见证者和骨干力量。安诺优达以此为核心,集合了国内外一大批优秀的高通量测序技术的骨干研发人员,吸引了来自生物学、医学、数学、计算机、物理、化学等不同行业和领域的一流人才,并形成了由博士、硕士和学士等组成的合理人才队伍梯队,共同推动公司的研发和产业快速健康发展。


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Edith Heard    特聘科学顾问

英国皇家学会院士、法国国家科学研究院和居里研究所教授

 

Edith   Heard 院士先后在剑桥大学、巴斯德研究所和英国帝国癌症研究基金会等机构从事基因组学相关研究,在细胞发育和肿瘤发生相关基因调控机制、人类X染色体失活、染色体三维构象与疾病发生等领域具有国际领先研究水平。在Cell 、Science、Nature等国际学术期刊发表了150余篇论文。

Edith Heard 近年发表文章PubMed链接 >>

1.   Giorgetti L, Galupa R, Nora EP, Piolot T, Lam F, Dekker J, Tiana G, Heard E. Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription[J]. Cell, 2014, 157(4):950-63.

2. Heard E, Martienssen RA. Transgenerational epigenetic inheritance: myths and mechanisms[J]. Cell, 2014, 157(1):95-109. 

3. Gendrel AV, Attia M, Chen CJ, Diabangouaya P, Servant N, Barillot E, Heard E. Developmental dynamics and disease potential of random monoallelic gene expression[J]. Dev Cell, 2014, 28(4):366-80. 

4. Schulz EG, Meisig J, Nakamura T, Okamoto I, Sieber A, Picard C, Borensztein M, Saitou M, Blüthgen N, Heard E. The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network[J]. Cell Stem Cell, 2014, 14(2):203-16. 

5. da Rocha ST, Boeva V, Escamilla-Del-Arenal M, Ancelin K, Granier C, Matias NR, Sanulli S, Chow J, Schulz E, Picard C, Kaneko S, Helin K, Reinberg D, Stewart AF, Wutz A, Margueron R, Heard E. Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome[J]. Mol Cell, 2014, 53(2):301-16. 

6. Giorgetti L, Servant N, Heard E. Changes in the organization of the genome during the mammalian cell cycle[J]. Genome Biol, 2013, 14(12):142.

7. Seitan VC, Faure AJ, Zhan Y, McCord RP, Lajoie BR, Ing-Simmons E, Lenhard B, Giorgetti L, Heard E, Fisher AG, Flicek P, Dekker J, Merkenschlager M. Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments[J]. Genome Res, 2013, 23(12):2066-77. 

8. de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. The pluripotent genome in three dimensions is shaped around pluripotency factors[J]. Nature, 2013, 501(7466):227-31.   

9. Gendrel AV, Apedaile A, Coker H, Termanis A, Zvetkova I, Godwin J, Tang YA, Huntley D, Montana G, Taylor S, Giannoulatou E, Heard E, Stancheva I, Brockdorff N. Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome[J]. Dev Cell, 2012, 23(2):265-279. 

10. Nora EP, Lajoie BR, Schulz EG, Giorgetti L, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J, Heard E. Spatial partitioning of the regulatory landscape of the X-inactivation centre[J]. Nature, 2012, 485(7398):381-385. 

11. O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Lavial F, Masui O, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation[J]. Cell Stem Cell, 2012, 10(1):33-46. 

12. Augui S, Nora EP, Heard E. Regulation of X-chromosome inactivation by the X-inactivation centre[J]. Nat Rev Genet, 2011, 12(6):429-442. 

13. Masui O, Bonnet I, Le Baccon P, Brito I, Pollex T, Murphy N, Hupé P, Barillot E, Belmont AS, Heard E. Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation[J]. Cell, 2011, 145(3):447-58. 

14. Okamoto I, Patrat C, Thépot D, Peynot N, Fauque P, Daniel N, Diabangouaya P, Wolf JP, Renard JP, Duranthon V, Heard E. Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development[J]. Nature, 2011, 472(7343):370-374. 

15. Heard E, Tishkoff S, Todd JA, Vidal M, Wagner GP, Wang J, Weigel D, Young R. Ten years of genetics and genomics: what have we achieved and where are we heading?[J]. Nat Rev Genet, 2010, 11(10):723-733. 

16. Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E. LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation[J]. Cell, 2010, 141(6):956-969. 

17. Nora EP, Heard E. X chromosome inactivation: when dosage counts[J]. Cell, 2009, 139(5):865-867. 


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Daniel Gautheret    特聘科学顾问

法国国家科学研究院和巴黎第十一大学教授


Daniel     Gautheret教授主要从事基因组研究、RNA结构与功能以及基因表达等方面的学术研究。先后在Science、Nucleic Acids Research、BMC Genomics 等知名期刊发表超过80篇学术论文。

Daniel Gautheret 近年发表文章PubMed链接 >>

1. Damm F, Mylonas E, Cosson A, et al. Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients[J]. Cancer Discov, 2014, 4(9):1088-1101. 

2. Lehmann J, Jossinet F, Gautheret D. A universal RNA structural motif docking the elbow of tRNA in the ribosome, RNAse P and T-box leaders[J]. Nucleic Acids Res, 2013, 41(10):5494-5502. 

3. Thiollier C, Lopez CK, Gerby B, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models[J]. J Exp Med, 2012, 209(11):2017-2031.

4. Ott A, Idali A, Marchais A, Gautheret D. NAPP: the Nucleic Acid Phylogenetic Profile Database[J]. Nucleic Acids Res, 2012, 40(Database issue):D205-209.

5. Naville M, Gautheret D. Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation[J]. Genome Biol, 2010, 11(9):R97.

6. Bohn C, Rigoulay C, Chabelskaya S, et al. Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism[J]. Nucleic Acids Res, 2010, 38(19):6620-6636. 

7. Marchais A, Naville M, Bohn C, Bouloc P, Gautheret D. Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles[J]. Genome Res, 2009, 19(6):1084-1092. 

8. Koscielny G, Le Texier V, Gopalakrishnan C, Gautheret D, et al. ASTD: The Alternative Splicing and Transcript Diversity database[J]. Genomics, 2009, 93(3):213-220. 

10. Espagne E, Lespinet O, Malagnac F, Gautheret D, et al. The genome sequence of the model ascomycete fungus Podospora anserina[J]. Genome Biol, 2008, 9(5):R77.



安诺优达CEO陈重建照片PS000.jpg


陈重建  博士    总裁 


中山大学和法国巴黎十一大学双博士学位,曾在法国居里研究所从事博士后研究,在生物信息、非编码RNA、高通量测序、胚胎干细胞和癌症基因组等领域有丰富的研究经验;曾先后在Science、Developmental Cell、Bioinformatics、RNA Methods等高水平杂志上发表文章;由他开发的多项基因组序列分析与RNA表达分析流程和算法,被学术界广泛引用。2012年陈博士作为海外高层次人才被引进回国,联合创办安诺优达基因科技有限公司,现为公司总裁。 


陈重建博士近年发表文章PubMed链接 >>

1. Luca Giorgetti, Bryan R. Lajoie, Ava C. Carter, Chong Jian Chen, et al. Structural organization of the inactive X chromosome in the mouse[J]. Nature, 2016.

2. Gendrel AV, Attia M, Chen CJ, Diabangouaya P, Servant N, Barillot E, Heard E. Developmental dynamics and disease potential of random monoallelic gene expression[J]. Dev Cell, 2014, 28(4):366-380. 

3. Leng XM, Diao LT, Li B, Bi YZ, Chen CJ, Zhou H, Qu LH. The ribosomal protein rpl26 promoter is required for its 3' sense terminus ncRNA transcription in Schizosaccharomyces pombe, implicating a new transcriptional mechanism for ncRNAs[J]. Biochem Biophys Res Commun, 2014, 444(1):86-91. 

4. Ciaudo C, Jay F, Okamoto I, Chen CJ, Sarazin A, Servant N, Barillot E, Heard E, Voinnet O. RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells[J]. PLoS Genet, 2013, 9(11):e1003791. 

5. Chen CJ, Heard E. Small RNAs derived from structural non-coding RNAs[J]. Methods, 2013, 63(1):76-84. 

6. Chen CJ, Servant N, Toedling J, et al. ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data[J]. Bioinformatics, 2012, 28(23):3147-9. 

7. Servant N, Lajoie BR, Nora EP, Giorgetti L, Chen CJ, Heard E, Dekker J, Barillot E. HiTC: exploration of high-throughput 'C' experiments[J]. Bioinformatics, 2012, 28(21):2843-4. 

8. Chen CJ, liu Q, Zhang YC, Qu LH, Chen YQ, Gautheret D. Genome-wide discovery and analysis of microRNAs and other small RNAs from rice embryogenic callus[J]. RNA Biol, 2011, 8(3):538-547.

9. Chen CJ, Zhou H, Chen YQ, Qu LH, Gautheret D. Plant noncoding RNA gene discovery by "single-genome comparative genomics"[J]. RNA, 2011, 17(3):390-400. 

10. Chen CL, Chen CJ, Vallon O, Huang ZP, Zhou H, Qu LH. Genomewide analysis of box C/D and box H/ACA snoRNAs in Chlamydomonas reinhardtii reveals an extensive organization into intronic gene clusters[J]. Genetics, 2008, 179(1):21-30. 

11. Merchant SS, Prochnik SE, Vallon O, Chen CJ, et al. The Chlamydomonas genome reveals the evolution of key animal and plant functions[J]. Science, 2007, 318(5848):245-250.

12. Huang ZP, Chen CJ, Zhou H, Li BB, Qu LH. A combined computational and experimental analysis of two families of snoRNA genes from Caenorhabditis elegans, revealing the expression and evolution pattern of snoRNAs in nematodes[J]. Genomics, 2007, 89(4):490-501.


 

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